BIOL 340 - Cell & Molecular Biology
Meets
7:30 T-Th, Scales Rm 226
Instructor: Art Chadwick (chadwick@swau.edu)
Textbook: Lodish et. al. Molecular Cell Biology. Fifth edition. Freeman & Co. N.Y.
"The work of creation can never be explained by science. What science can explain the mystery of life?" -Ellen G. White, Testimonies, 8:258
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Section I. The History and Development of CMB Read for this class period: |
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Aug. |
28 |
History of CMB and introduction to the subject |
p. 1-30 |
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Section II. The Cellular and Molecular Basis of Life. |
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30 |
Biomolecules and energetics |
p. 31-62 Problems 1, 2, 3, 5, 7 |
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Sept |
4 |
Protein structure and function |
p. 63-78 Problems 1, 2 |
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6 |
Proteins |
p. 78-92 Problems 3, 5, 7 |
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11 |
Enzymes |
p. 92-110 Analyze data, a-d |
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13 |
Basic properties of nucleic acids |
p. 111-119 Problems 2, 3, 4 |
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18 |
Transcription |
p. 120-132 Problems 6, 8 |
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20 |
Translation |
p. 132-139 Analyze data a-c |
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25 |
DNA repair and cell and viral culture |
p. 139-164 Problems 12, 14, 15 |
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27 |
No reading |
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Oct. |
2 |
Molecular Genetic techniques |
p. 165-176 Problems 5, 6, 7 |
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4 |
Cloning |
p. 176-190 Problems 5, 6, 7 |
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9 |
Gene knockout and other techniques |
P. 191-214 Analyze data a-e |
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Section III. Gene Expression, Structure and Replication. |
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Oct. |
11 |
Architecture of eukaryotic genes |
p. 215-236 Problems 2, 4, 5 |
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16 |
Large scale analysis of genes and chromosomes |
p. 237-268 Problems 9, 11, 12 An. data a-c |
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18 |
Regulation of eukaryotic genes I |
p. 269-282 Problems 1, 3, 5, 7 |
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23 |
Regulation of eukaryotic genes II |
p. 282-296 Problems 12, 14, 15 |
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25 |
Regulation of eukaryotic genes III |
p. 296-322 Analyze data a-c |
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30 |
No reading |
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1 |
Post-transcriptional gene control I |
p. 323-337 Problems 1, 2, 5 |
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6 |
Post-transcriptional gene control II |
p. 337-358 Problems 6, 9, 12 |
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8 |
Post-transcriptional gene control III |
p. 358-370 Analyze data a-d |
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Section IV. Cell Structure and Function. |
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Nov. |
13 |
The cell |
p. 371-405 Analyze data a-d |
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15 |
The cell membrane |
p. 411-436 Analyze data a-c |
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20 |
Protein transport I |
p. 437-476 Analyze data a-c |
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22 |
Thanksgiving |
No reading |
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27 |
Protein transport II |
p. 479-510 Analyze data a-d |
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29 |
p. 511-532 Problems 10, 11, 15 |
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Dec. |
4 |
Bioenergetics |
p. 533-557 Problems 2, 3, 4, 7 |
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6 |
Bioenergetics |
p. 557-578 Analyze data a-d |
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dd |
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Final Exam Dec. 11 7:30 A.M. |
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Grades and Policies:
- Lecture: This class begins at
7:30. Please do not make the
mistake of thinking that means 7:35, or whenever you happen to get there.
Lecture is a critical part of this course. Cell & molecular biology is
at the cutting edge of science. A huge amount of material is discovered
and integrated in this field every year. If you miss lecture you are
missing information that may not yet be in the textbook. This also means
reading the text is not optional since much material from a wide variety
of disciplines not covered in lecture is included in the text. Exams will
be drawn from the lecture and the problems in the book, and from the
reading material.
- Homework: You will be assigned
homework from the “Problems” and “Analyze the Data” section in the back of
each chapter. This homework is due at the start of each lecture (7:30). No late assignments will be accepted.
While collaboration for purposes of problem solutions is healthy and is
permissible, your answers must be your own, composed and written by you. Answers
seeming to reflect too closely those of other students will be rejected
(both parties). The safest procedure is to separate yourself from others
while generating your responses, and to avoid sharing the text of your
responses with others (this will hurt both of you).
- Examination
policy:
Makeup: No makeup examinations will be given. If the instructor is
notified in advance of an acceptable circumstance, the exam grade will be
prorated. Otherwise a zero will be recorded for a missed exam. No written
materials of any kind should be brought into the examination room with
you. Paper will be provided, a pencil or pen is all you need. The presence
of any form of study cards, sheets etc., on or around your persons will be
grounds for dismissal from this course with a grade of F. (That will be
the least of your worries...)
- Grades: Grades will be based
upon three examinations and on homework. The third (final) exam will
consist of two parts: the first, a sectional exam over the last third of
the course; the second, a review exam including material from all three
sectional exams.
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3 sectional exams |
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45% |
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Final exam |
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40% |
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Homework |
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15% |
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Total |
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100% |
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90 or higher |
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A |
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80 or higher |
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B |
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65 or higher |
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C |
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50 or higher |
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D |
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Below 50 |
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F |
E.
Learning
objectives and protocols: The objective of this course is to enable you to
obtain an intelligent understanding of the frontiers of science in molecular biology.
This will prepare you to advance in whatever discipline you should choose to
pursue. Molecular biology is the forefront of our discipline and a working
knowledge is essential whether you should choose to become a molecular
biologist, a taxonomist, an entomologist or even a paleontologist. It goes without saying that those pursuing
educations in professional areas will also need this knowledge. This course
will be intellectually challenging and will require at least 3 hours of outside
study time for each 80 minute class period. Learning studies have demonstrated
that the best time to review materials from class and expand your knowledge
about a lecture is immediately following class. For some, this will not be
possible, but for those who can, plan on studying in close proximity to class
time. Discipline your time. Choose set
times each week to study for this class. Do not postpone study time with the
thought that you can make the time up later (like that will ever happen….).
Because the 6th edition of the book is extensively altered from
previous editions, materials from other years, including exams, will not be
useful study guides.
- Severe Weather Protocol
-In the
rare event of severe weather, an announcement will be made between 9:00
and 10:30 p.m. indicating that classes will be delayed or cancelled - or
that the university will be open as usual on the following day. If
it is not determined until early morning that classes must be delayed or
cancelled, an announcement will be made by 6:00 a.m. You may check
the following for official delay or closing announcements: 88.3 FM
KJCR, NBC 5 KXAS TV, or the University switchboard
operator at (817) 645-3921.